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Research

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Research Call

DAFM Reference

Lead(Collaborating)Institution

DAFM Award

DAFM National Call 2015 15/S/669 UCC €195,086

Project Title:

Small-molecule Modulators of Oomycete Calcium Channels

Project Coordinator:

Dr. John Mackrill

Project Abstract

Water moulds are fungus-like in appearance and cause disease in commercially important plants, fish and crustaceans. Late blight of potatoes is a water mould estimated to cost Irish agriculture about €10 million per annum, due to crop losses and expenditure on fungicides. Water moulds are becoming resistant to certain fungicides, whereas the use of other protective chemicals may be prohibited under upcoming EU legislation. Like all other cellular life, water moulds can respond to stimuli from their environments with increases in calcium ions, which in turn control functions like growth, reproduction, movement and death. Water moulds possess a unique type of ion channel, or molecular switch, which allows calcium influx and which is not found in animals or plants. The aim of this project is to develop new types of anti-water mould pesticides, which work by opening these channels, allowing toxic amounts of calcium to enter their cells.

Final Report:

Not available yet.