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Research Call

DAFM Reference

Lead(Collaborating)Institution

DAFM Award

DAFM National Call 2014 14/F/821 Teagasc MFRC, (UCC, CUMH) €597,246

Project Title:

Foods solutions for replenishing disrupted microbiota in toddlers

Project Coordinator:

Prof Catherine Stanton

Project Abstract

The first two years of life represents the most critical period for dietary interventions to improve child growth/development. This is the period when intestinal microbiota, a vital asset for health and neurodevelopment (Borre et al., 2014) is established. Nutrition influences gut microbiome evolution, with breast feeding in early life the gold standard. Malnutrition is caused not only by nutrient deprivation/imbalance, but also by disrupted gut microbiota, leading to impaired nutrient availability and energy harvesting from the diet (Tilg and Moschen, 2013). Perturbation of optimum microbiota development, arising from preterm birth or antibiotics have likely long-term implications for microbial diversity and consequent health. Little is known about how early gut microbiome is positively manipulated through nutrition. In ongoing studies, we are assessing optimum gut microbiome development in initially breastfed infants from birth to 2 years (INFANTMET) and impact of perturbed microbiota (due to C-section delivery and antibiotic treatment following birth) on health and neurodevelopment to 2 years in the recently FP7 funded MYNEWGUT study. In TODDLERFOOD, we aim to identify food solutions for replenishing a disrupted microbiota of the latter group towards that of INFANTMET infants, so as to enhance microbial diversity in all children, for better long-term health and neurodevelopment.

Final Report:

Not available yet.