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Research Call

DAFM Reference

Lead(Collaborating)Institution

DAFM Award

DAFM National Call 2010 10RDTMFRC705 Teagasc (UCC) €398,858

Project Title:

Infant Nutrition for Programming the Gut Microbiota in Neonates

Project Coordinator:

Dr Catherine Stanton

Project Abstract

Establishment of the intestinal microbiota commences at birth. The microbiota has a major role in protection against pathogens, maturation of the immune system and metabolic welfare of the host. In terms of infant health, it is imperative to understand how early infant nutrition influences the development of a healthy gut microbiota. Breast Milk is the Gold Standard feeding regime for newborn infants and represents a baseline for the functional performance of infant formulae. Interestingly, no studies have yet been reported to reveal the evolving composition and functionality of the intestinal microbiota in infants exclusively fed breast milk, where high throughput sequencing was employed to detail the gut microbial ecology. The objective of this platform study is to define the composition and functional performance of the baseline microbiota in developing breast fed infants over time, using state-of-the-art pryo-sequencing technology. This will provide Infant Milk Formula manufacturers with an essential baseline composition, with which to compare different formulations and ingredients. Thus, the project will provide new opportunities for optimisation of infant milk formula composition, with appropriate new bioactive ingredients such as milk fractions, probiotics and prebiotics to effectively programme the early infant gut microbiota in a manner closer to mothers milk.

Final Report:

Not available yet.